Antiaging agents: safe
interventions to slow aging and healthy life span extension
Ji-Kai Liu
Natural Products and Bioprospecting https://doi.org/10.1007/s13659-022-00339-y
Abstract
：Human longevity has
increased dramatically during the past century. More than 20% of the 9 billion
population of the world will exceed the age of 60 in 2050. Since the last three
decades, some interventions and many preclinical studies have been found to
show slowing aging and increasing the healthy lifespan of organisms from yeast,
flies, rodents to nonhuman primates. The interventions are classified into two
groups: lifestyle modifications and pharmacological/
genetic
manipulations. Some genetic pathways have been characterized to have a specific
role in controlling aging and lifespan. Thus, all genes in the pathways are
potential antiaging targets. Currently, many antiaging compounds target the
calorie-restriction mimetic, autophagy induction,and putative enhancement of
cell regeneration, epige-netic modulation of gene activity such as inhibition
of histone deacetylases and DNA methyltransferases, are under development. It
appears evident that the exploration of new targets for these antiaging agents
based on biogeron-tological research provides an incredible opportunity for the
healthcare and pharmaceutical industries. The present review focus on the
properties of slow aging and healthy life span extension of natural products
from various biologi-cal resources, endogenous substances, drugs, and synthetic
compounds, as well as the mechanisms of targets for antiaging evaluation. These
bioactive compounds that could benefit healthy aging and the potential role of
life span extension are discussed.
Keywords: Antiaging agents, Antiaging targets, Healthy lifespan extension, Natural
products, Endogenous substances, Longevity