The Emerging Role of the Gut
Microbiome in Cardiovascular Disease: Current Knowledge and Perspectives
Panagiotis D. Papadopoulos , Christina T sigalou , Pipitsa N. V alsamaki ,et
al.
Biomedicines 2022, 10, 948; https://www.mdpi.com/journal/biomedicine
Abstract: The collection of normally non-pathogenic microorganisms that mainly inhabit
our gut lumen shapes our health in many ways. Structural and functional
perturbations in the gut microbial pool, known as “dysbiosis”, have been proven
to play a vital role in the pathophysiology of several diseases, including
cardiovascular disease (CVD). Although therapeutic regimes are available to
treat this group of diseases, they have long been the main cause of mortality
and morbidity worldwide.While age, sex, genetics, diet, tobacco use, and
alcohol consumption are major contributors (World Health Organization, 2018),
they cannot explain all of the consequences of CVD. In addition to the abovementioned
traditional risk factors, the constant search for novel preventative and
curative tools has shed light on the involvement of gut bacteria and their
metabolites in the pathogenesis of CVD.In this narrative review, we will
discuss the established interconnections between the gut microbiota and CVD, as
well as the plausible therapeutic perspectives.
Keywords: microbiome; cardiovascular disease; gut dysbiosis; CVD; bacterial metabolites; TMAO