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甜菊糖和塔格糖摄入对胰岛素抵抗患者的代谢参数和食欲/饱腹感的急性反应

Acute responses of stevia and d‑tagatose intake on metabolic parameters and appetite/satiety in insulin resistance    

Verónica Sambra et al.

Clin Nutr ESPEN. 2022 Jun.    

Abstract    
Objective: To examine the effects of d-­‐‑tagatose or stevia preloads on carbohydrate metabolism markers after an oral glucose load, as    well as subjective and objective appetite in women with insulin resistance (IR).    
Research design and methods: Randomized controlled crossover study. Women with IR without T2DM (n = 33; aged 23.4 ± 3.8; BMI    28.1 ± 3.4 kg × m‑2) underwent three oral glucose loads (3h each) on three different days. Ten min before oral glucose load, volunteers    consumed a preload of 60mL water (control), 60 mL water with    stevia (15.3 mg),  or d‑tagatose (5000    mg). Serum glucose and  C‑peptide were evaluated  at -­10, 30‑, 60‑, 90‑, 120‑, and 180‑min. Subjective appetite was determined with a visual analog  scale.  Food intake was measured at ad libitum buffet after 180 min.    

Results: C-­peptide iAUC was significantly higher for stevia (median (IQR): 1033 (711‑1293) ng × min × L-­1)  vs. d-­tagatose (794 (366-­‐‑1134) ng × min × L‑1; P = 0.001) or control (730 (516‑1078) ng × min × L‑1; P = 0.012). At 30‑ and 60‑min serum glucose was higher for stevia vs other conditions (P < 0.01). Volunteers  reported greater satiety for stevia and d‑tagatose vs. control at 60 min and    greater desire to eat for stevia vs. control at 120‑ min (all P < 0.05). Objective appetite did not vary by condition (P = 0.06).    
Conclusions: Our findings suggest that these NNS are not inert. Stevia intake produced an acute response on C‑peptide release while    increased serum glucose at earlier times. It is possible that NNS affects subjective but not objective appetite. This trial is registered at    
clinicaltrials.gov as NCT04327245.    

Clinical trial registry: NCT04327245.    
Keywords: Appetite; C‑peptide; Glycemia; Insulin resistance; Satiety; Stevia; d‑tagatose.    

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